Paul Sieber, MD

Dr. Sieber is the Medical Director for Clinical Trials at Keystone Urology. He went to Purdue University and obtained his undergraduate degree in Biology before receiving his medical degree from Indiana University. He did his residency in general surgery and urology at the M.S. Hershey Medical Center, Penn State University. He has been involved with clinical trials for 20 years having worked on more than 200 studies. The bulk of these have focused on prostate cancer. Dr. Sieber is very enthusiastic about clinical trials and research as he looks at what can benefit his patients in the future. Many of today’s state-of-the-art treatments for prostate cancer have been investigated right here in Lancaster including Xgeva, Zytiga, Xtandi, Erleada, and Firmagon. Numerous diagnostic tests including OncotypeDX, Prolaris, Decipher, and 4K score have also been studied here. Furthermore, Keystone Urology has been a long-term participant in CAPSURE, an observational database with more than 150 publications. Dr. Sieber has authored numerous peer-reviewed articles and presented many posters at meetings including the AUA, ASCO, ASCO GU, SUO, and SIU.

Dr. Sieber met his wife of over 35 years while at Hershey Medical Center and has three children. Dr. Sieber enjoys spending time with his wife, gardening, exercising / cycling, and traveling.




Undergraduate degree in Biology from Purdue University
Medical Degree from Indiana University
Internship in General Surgery at Hershey Medical Center
Residency in Urology at Hershey Medical Center


Advanced Prostate Cancer
Bone Health
Urological Research
General Urology

Awards and Recognition

Board Certified by the American Board of Urology
Fellow, American College of Surgeons


Lancaster Urology, Laboratory Medical Director
Lancaster Urology, Principal Investigator for Clinical Trials

What our Patients Say

“Dr. Sieber and his research team continue to help me with my difficult situation. All have been very caring and understanding. Hope they can keep me alive a while longer. I appreciate their expertise.”

“Dr. Sieber was very thorough in addressing my situation and made me feel at ease and comfortable. He responded to my inquiries and also those my wife posed in a very professional and knowledgeable manner but with some humor to relieve our tension. I am extremely satisfied with the treatment Dr. Sieber is providing.”

“Appreciate how well and thoroughly he explains things! Always makes the appointment delightful”

“I feel I am an informed patient and Dr. Sieber make me part of the decision making process by the fact alternate courses of ongoing treatment and the risks.”

“I am convinced that Dr. Sieber has saved my life and continues to prolong my health.”

“Dr. Sieber was so comforting in talking with me and explained things to me as a teacher. Not rushed and wanted to listen to me. He is exceptional. I moved down to Lancaster County from the State College area. Very fortunate to connect with Dr. Sieber as my new Urologist.”